Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
Identifieur interne : 000E24 ( Main/Exploration ); précédent : 000E23; suivant : 000E25Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
Auteurs : Ana Clara Monsalvo [Argentine] ; Juan P. Batalle [Argentine] ; M. Florencia Lopez [Argentine] ; Jens C. Krause [États-Unis] ; Jennifer Klemenc [États-Unis] ; Johanna Zea [Argentine, États-Unis] ; Bernardo Maskin [Argentine] ; Jimena Bugna [Argentine] ; Carlos Rubinstein [Argentine] ; Leandro Aguilar [Argentine] ; Liliana Dalurzo [Argentine] ; Romina Libster [Argentine] ; Vilma Savy [Argentine] ; Elsa Baumeister [Argentine] ; Liliana Aguilar [Argentine] ; Graciela Cabral [Argentine] ; Julia Font [Argentine] ; Liliana Solari [Argentine] ; Kevin P. Weller [États-Unis] ; Joyce Johnson [États-Unis] ; Marcela Echavarria [Argentine] ; Kathryn M. Edwards [États-Unis] ; James D. Chappell [États-Unis] ; James E. Crowe [États-Unis] ; John V. Williams [États-Unis] ; Guillermina A. Melendi [Argentine, États-Unis] ; Fernando P. Polack [Argentine, États-Unis]Source :
- Nature medicine [ 1078-8956 ] ; 2010.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (immunologie), Antigènes viraux (immunologie), Complexe antigène-anticorps (immunologie), Complément C3 (analyse), Cytokines (sang), Facteurs de l'âge, Grippe humaine (anatomopathologie), Grippe humaine (immunologie), Grippe humaine (sang), Grippe humaine (virologie), Humains, Interféron alpha (sang), Interféron bêta (sang), Jeune adulte, Poumon (anatomopathologie), Poumon (immunologie), Poumon (virologie), Réactions croisées (immunologie), Sous-type H1N1 du virus de la grippe A (immunologie).
- MESH :
- analyse : Complément C3.
- anatomopathologie : Grippe humaine, Poumon.
- immunologie : Anticorps antiviraux, Antigènes viraux, Complexe antigène-anticorps, Grippe humaine, Poumon, Réactions croisées, Sous-type H1N1 du virus de la grippe A.
- sang : Cytokines, Grippe humaine, Interféron alpha, Interféron bêta.
- virologie : Grippe humaine, Poumon.
- Adolescent, Adulte, Adulte d'âge moyen, Facteurs de l'âge, Humains, Jeune adulte.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Antibodies, Viral (immunology), Antigen-Antibody Complex (immunology), Antigens, Viral (immunology), Complement C3 (analysis), Cross Reactions (immunology), Cytokines (blood), Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza, Human (blood), Influenza, Human (immunology), Influenza, Human (pathology), Influenza, Human (virology), Interferon-alpha (blood), Interferon-beta (blood), Lung (immunology), Lung (pathology), Lung (virology), Middle Aged, Young Adult.
- MESH :
- chemical , analysis : Complement C3.
- chemical , blood : Cytokines, Interferon-alpha, Interferon-beta.
- chemical , immunology : Antibodies, Viral, Antigen-Antibody Complex, Antigens, Viral.
- blood : Influenza, Human.
- immunology : Cross Reactions, Influenza A Virus, H1N1 Subtype, Influenza, Human, Lung.
- pathology : Influenza, Human, Lung.
- virology : Influenza, Human, Lung.
- Adolescent, Adult, Age Factors, Humans, Middle Aged, Young Adult.
Abstract
Pandemic influenza viruses often cause severe disease in middle-aged adults without preexistent co-morbidities. The mechanism of illness associated with severe disease in this age group is not well understood
Url:
DOI: 10.1038/nm.2262
PubMed: 21131958
PubMed Central: 3034774
Affiliations:
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Le document en format XML
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<author><name sortKey="Maskin, Bernardo" sort="Maskin, Bernardo" uniqKey="Maskin B" first="Bernardo" last="Maskin">Bernardo Maskin</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Hospital Nacional Prof. Alejandro Posadas, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Hospital Nacional Prof. Alejandro Posadas, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bugna, Jimena" sort="Bugna, Jimena" uniqKey="Bugna J" first="Jimena" last="Bugna">Jimena Bugna</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Fundacion INFANT, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Fundacion INFANT, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rubinstein, Carlos" sort="Rubinstein, Carlos" uniqKey="Rubinstein C" first="Carlos" last="Rubinstein">Carlos Rubinstein</name>
<affiliation wicri:level="1"><nlm:aff id="A4"> Hospital Dr Federico Abete, Malvinas Argentinas, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Hospital Dr Federico Abete, Malvinas Argentinas, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aguilar, Leandro" sort="Aguilar, Leandro" uniqKey="Aguilar L" first="Leandro" last="Aguilar">Leandro Aguilar</name>
<affiliation wicri:level="1"><nlm:aff id="A4"> Hospital Dr Federico Abete, Malvinas Argentinas, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Hospital Dr Federico Abete, Malvinas Argentinas, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dalurzo, Liliana" sort="Dalurzo, Liliana" uniqKey="Dalurzo L" first="Liliana" last="Dalurzo">Liliana Dalurzo</name>
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<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Hospital Italiano, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Libster, Romina" sort="Libster, Romina" uniqKey="Libster R" first="Romina" last="Libster">Romina Libster</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Fundacion INFANT, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Fundacion INFANT, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Savy, Vilma" sort="Savy, Vilma" uniqKey="Savy V" first="Vilma" last="Savy">Vilma Savy</name>
<affiliation wicri:level="1"><nlm:aff id="A6"> ANLIS Dr Carlos G Malbran, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> ANLIS Dr Carlos G Malbran, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baumeister, Elsa" sort="Baumeister, Elsa" uniqKey="Baumeister E" first="Elsa" last="Baumeister">Elsa Baumeister</name>
<affiliation wicri:level="1"><nlm:aff id="A6"> ANLIS Dr Carlos G Malbran, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> ANLIS Dr Carlos G Malbran, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aguilar, Liliana" sort="Aguilar, Liliana" uniqKey="Aguilar L" first="Liliana" last="Aguilar">Liliana Aguilar</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Hospital Nacional Prof. Alejandro Posadas, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Hospital Nacional Prof. Alejandro Posadas, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cabral, Graciela" sort="Cabral, Graciela" uniqKey="Cabral G" first="Graciela" last="Cabral">Graciela Cabral</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Hospital Nacional Prof. Alejandro Posadas, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Hospital Nacional Prof. Alejandro Posadas, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Font, Julia" sort="Font, Julia" uniqKey="Font J" first="Julia" last="Font">Julia Font</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Hospital Nacional Prof. Alejandro Posadas, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Hospital Nacional Prof. Alejandro Posadas, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Solari, Liliana" sort="Solari, Liliana" uniqKey="Solari L" first="Liliana" last="Solari">Liliana Solari</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> Hospital Nacional Prof. Alejandro Posadas, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Hospital Nacional Prof. Alejandro Posadas, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weller, Kevin P" sort="Weller, Kevin P" uniqKey="Weller K" first="Kevin P." last="Weller">Kevin P. Weller</name>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Pediatrics, Vanderbilt University, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea> Department of Pediatrics, Vanderbilt University, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Johnson, Joyce" sort="Johnson, Joyce" uniqKey="Johnson J" first="Joyce" last="Johnson">Joyce Johnson</name>
<affiliation wicri:level="2"><nlm:aff id="A7"> Department of Pathology, Vanderbilt University, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea> Department of Pathology, Vanderbilt University, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Echavarria, Marcela" sort="Echavarria, Marcela" uniqKey="Echavarria M" first="Marcela" last="Echavarria">Marcela Echavarria</name>
<affiliation wicri:level="1"><nlm:aff id="A8"> Department of Microbiology, CEMIC, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Department of Microbiology, CEMIC, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M." last="Edwards">Kathryn M. Edwards</name>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Pediatrics, Vanderbilt University, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea> Department of Pediatrics, Vanderbilt University, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chappell, James D" sort="Chappell, James D" uniqKey="Chappell J" first="James D." last="Chappell">James D. Chappell</name>
<affiliation wicri:level="2"><nlm:aff id="A7"> Department of Pathology, Vanderbilt University, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea> Department of Pathology, Vanderbilt University, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Pediatrics, Vanderbilt University, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea> Department of Pediatrics, Vanderbilt University, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Williams, John V" sort="Williams, John V" uniqKey="Williams J" first="John V." last="Williams">John V. Williams</name>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Pediatrics, Vanderbilt University, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea> Department of Pediatrics, Vanderbilt University, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Melendi, Guillermina A" sort="Melendi, Guillermina A" uniqKey="Melendi G" first="Guillermina A." last="Melendi">Guillermina A. Melendi</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Fundacion INFANT, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Fundacion INFANT, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Pediatrics, Vanderbilt University, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea> Department of Pediatrics, Vanderbilt University, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Polack, Fernando P" sort="Polack, Fernando P" uniqKey="Polack F" first="Fernando P." last="Polack">Fernando P. Polack</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Fundacion INFANT, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea> Fundacion INFANT, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2"> Department of Pediatrics, Vanderbilt University, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea> Department of Pediatrics, Vanderbilt University, Nashville</wicri:cityArea>
</affiliation>
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</analytic>
<series><title level="j">Nature medicine</title>
<idno type="ISSN">1078-8956</idno>
<idno type="eISSN">1546-170X</idno>
<imprint><date when="2010">2010</date>
</imprint>
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<term>Adult</term>
<term>Age Factors</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antigen-Antibody Complex (immunology)</term>
<term>Antigens, Viral (immunology)</term>
<term>Complement C3 (analysis)</term>
<term>Cross Reactions (immunology)</term>
<term>Cytokines (blood)</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza, Human (blood)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (pathology)</term>
<term>Influenza, Human (virology)</term>
<term>Interferon-alpha (blood)</term>
<term>Interferon-beta (blood)</term>
<term>Lung (immunology)</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Middle Aged</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Antigènes viraux (immunologie)</term>
<term>Complexe antigène-anticorps (immunologie)</term>
<term>Complément C3 (analyse)</term>
<term>Cytokines (sang)</term>
<term>Facteurs de l'âge</term>
<term>Grippe humaine (anatomopathologie)</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (sang)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Interféron alpha (sang)</term>
<term>Interféron bêta (sang)</term>
<term>Jeune adulte</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (immunologie)</term>
<term>Poumon (virologie)</term>
<term>Réactions croisées (immunologie)</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Complement C3</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term>
<term>Interferon-alpha</term>
<term>Interferon-beta</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term>
<term>Antigen-Antibody Complex</term>
<term>Antigens, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Complément C3</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Antigènes viraux</term>
<term>Complexe antigène-anticorps</term>
<term>Grippe humaine</term>
<term>Poumon</term>
<term>Réactions croisées</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cross Reactions</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza, Human</term>
<term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Influenza, Human</term>
<term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cytokines</term>
<term>Grippe humaine</term>
<term>Interféron alpha</term>
<term>Interféron bêta</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
<term>Lung</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Facteurs de l'âge</term>
<term>Humains</term>
<term>Jeune adulte</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Pandemic influenza viruses often cause severe disease in middle-aged adults without preexistent co-morbidities. The mechanism of illness associated with severe disease in this age group is not well understood<xref rid="R1" ref-type="bibr">1</xref>
–<xref rid="R10" ref-type="bibr">10</xref>
. Here, we demonstrate preexisting serum antibody that cross-reacts with, but does not protect against 2009 H1N1 influenza virus in middle-aged adults. Non-protective antibody is associated with immune complex(IC)-mediated disease after infection. High titers of serum antibody of low avidity for H1-2009 antigen, and low avidity pulmonary ICs against the same protein were detected in severely ill patients. Moreover, C4d deposition - a sensitive marker of complement activation mediated by ICs- was present in lung sections of fatal cases. Archived lung sections from adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a novel biological mechanism for the unusual age distribution of severe cases during influenza pandemics.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name>
</author>
<author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Itoh, Y" uniqKey="Itoh Y">Y Itoh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kobasa, D" uniqKey="Kobasa D">D Kobasa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Geiss, Gk" uniqKey="Geiss G">GK Geiss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name>
</author>
<author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perez Padilla, R" uniqKey="Perez Padilla R">R Perez-Padilla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hancock, K" uniqKey="Hancock K">K Hancock</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Bhat, N" uniqKey="Bhat N">N Bhat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delgado, Mf" uniqKey="Delgado M">MF Delgado</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reichert, T" uniqKey="Reichert T">T Reichert</name>
</author>
<author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name>
</author>
<author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H Nishiura</name>
</author>
<author><name sortKey="Christensen, Ra" uniqKey="Christensen R">RA Christensen</name>
</author>
<author><name sortKey="Mccullers, Ja" uniqKey="Mccullers J">JA McCullers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mauad, T" uniqKey="Mauad T">T Mauad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kobasa, D" uniqKey="Kobasa D">D Kobasa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perrone, La" uniqKey="Perrone L">LA Perrone</name>
</author>
<author><name sortKey="Plowden, Jk" uniqKey="Plowden J">JK Plowden</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A García-Sastre</name>
</author>
<author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lewis, De" uniqKey="Lewis D">DE Lewis</name>
</author>
<author><name sortKey="Gilbert, Be" uniqKey="Gilbert B">BE Gilbert</name>
</author>
<author><name sortKey="Knight, V" uniqKey="Knight V">V Knight</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Greenbaum, Ja" uniqKey="Greenbaum J">JA Greenbaum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnson, Tr" uniqKey="Johnson T">TR Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Regele, H" uniqKey="Regele H">H Regele</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Polack, Fp" uniqKey="Polack F">FP Polack</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hall, C" uniqKey="Hall C">C Hall</name>
</author>
<author><name sortKey="Douglas, Rg" uniqKey="Douglas R">RG Douglas</name>
</author>
<author><name sortKey="Simons, Rl" uniqKey="Simons R">RL Simons</name>
</author>
<author><name sortKey="Geiman, Jm" uniqKey="Geiman J">JM Geiman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salomon, R" uniqKey="Salomon R">R Salomon</name>
</author>
<author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Palacios, G" uniqKey="Palacios G">G Palacios</name>
</author>
</analytic>
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<affiliations><list><country><li>Argentine</li>
<li>États-Unis</li>
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<region><li>Tennessee</li>
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<tree><country name="Argentine"><noRegion><name sortKey="Monsalvo, Ana Clara" sort="Monsalvo, Ana Clara" uniqKey="Monsalvo A" first="Ana Clara" last="Monsalvo">Ana Clara Monsalvo</name>
</noRegion>
<name sortKey="Aguilar, Leandro" sort="Aguilar, Leandro" uniqKey="Aguilar L" first="Leandro" last="Aguilar">Leandro Aguilar</name>
<name sortKey="Aguilar, Liliana" sort="Aguilar, Liliana" uniqKey="Aguilar L" first="Liliana" last="Aguilar">Liliana Aguilar</name>
<name sortKey="Batalle, Juan P" sort="Batalle, Juan P" uniqKey="Batalle J" first="Juan P." last="Batalle">Juan P. Batalle</name>
<name sortKey="Baumeister, Elsa" sort="Baumeister, Elsa" uniqKey="Baumeister E" first="Elsa" last="Baumeister">Elsa Baumeister</name>
<name sortKey="Bugna, Jimena" sort="Bugna, Jimena" uniqKey="Bugna J" first="Jimena" last="Bugna">Jimena Bugna</name>
<name sortKey="Cabral, Graciela" sort="Cabral, Graciela" uniqKey="Cabral G" first="Graciela" last="Cabral">Graciela Cabral</name>
<name sortKey="Dalurzo, Liliana" sort="Dalurzo, Liliana" uniqKey="Dalurzo L" first="Liliana" last="Dalurzo">Liliana Dalurzo</name>
<name sortKey="Echavarria, Marcela" sort="Echavarria, Marcela" uniqKey="Echavarria M" first="Marcela" last="Echavarria">Marcela Echavarria</name>
<name sortKey="Font, Julia" sort="Font, Julia" uniqKey="Font J" first="Julia" last="Font">Julia Font</name>
<name sortKey="Libster, Romina" sort="Libster, Romina" uniqKey="Libster R" first="Romina" last="Libster">Romina Libster</name>
<name sortKey="Lopez, M Florencia" sort="Lopez, M Florencia" uniqKey="Lopez M" first="M. Florencia" last="Lopez">M. Florencia Lopez</name>
<name sortKey="Maskin, Bernardo" sort="Maskin, Bernardo" uniqKey="Maskin B" first="Bernardo" last="Maskin">Bernardo Maskin</name>
<name sortKey="Melendi, Guillermina A" sort="Melendi, Guillermina A" uniqKey="Melendi G" first="Guillermina A." last="Melendi">Guillermina A. Melendi</name>
<name sortKey="Polack, Fernando P" sort="Polack, Fernando P" uniqKey="Polack F" first="Fernando P." last="Polack">Fernando P. Polack</name>
<name sortKey="Rubinstein, Carlos" sort="Rubinstein, Carlos" uniqKey="Rubinstein C" first="Carlos" last="Rubinstein">Carlos Rubinstein</name>
<name sortKey="Savy, Vilma" sort="Savy, Vilma" uniqKey="Savy V" first="Vilma" last="Savy">Vilma Savy</name>
<name sortKey="Solari, Liliana" sort="Solari, Liliana" uniqKey="Solari L" first="Liliana" last="Solari">Liliana Solari</name>
<name sortKey="Zea, Johanna" sort="Zea, Johanna" uniqKey="Zea J" first="Johanna" last="Zea">Johanna Zea</name>
</country>
<country name="États-Unis"><region name="Tennessee"><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C." last="Krause">Jens C. Krause</name>
</region>
<name sortKey="Chappell, James D" sort="Chappell, James D" uniqKey="Chappell J" first="James D." last="Chappell">James D. Chappell</name>
<name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name>
<name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M." last="Edwards">Kathryn M. Edwards</name>
<name sortKey="Johnson, Joyce" sort="Johnson, Joyce" uniqKey="Johnson J" first="Joyce" last="Johnson">Joyce Johnson</name>
<name sortKey="Klemenc, Jennifer" sort="Klemenc, Jennifer" uniqKey="Klemenc J" first="Jennifer" last="Klemenc">Jennifer Klemenc</name>
<name sortKey="Melendi, Guillermina A" sort="Melendi, Guillermina A" uniqKey="Melendi G" first="Guillermina A." last="Melendi">Guillermina A. Melendi</name>
<name sortKey="Polack, Fernando P" sort="Polack, Fernando P" uniqKey="Polack F" first="Fernando P." last="Polack">Fernando P. Polack</name>
<name sortKey="Weller, Kevin P" sort="Weller, Kevin P" uniqKey="Weller K" first="Kevin P." last="Weller">Kevin P. Weller</name>
<name sortKey="Williams, John V" sort="Williams, John V" uniqKey="Williams J" first="John V." last="Williams">John V. Williams</name>
<name sortKey="Zea, Johanna" sort="Zea, Johanna" uniqKey="Zea J" first="Johanna" last="Zea">Johanna Zea</name>
</country>
</tree>
</affiliations>
</record>
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